Anthony Martial saved Manchester United's blushes as Ole Gunnar Solskjaer's side kicked off the Europa League knockout phase with a hard-fought 1-1 away draw at Club Brugge.
But there was a rousing win for Wolves, who thumped Espanyol 4-0 at Molineux, while Arsenal defeated Olympiacos 1-0 in Greece, in the first leg ties of the last 32 round.
Diogo Jota's hat-trick and a Ruben Neves' thunderbolt kept the European dream alive for Wolves, while Alexandre Lacazette scored the all important away goal for the Gunners.
Steven Gerrard's Rangers found themselves two goals down to Braga at Ibrox, before launching a 15-minute second half blitz to win 3-2.
Ianis Hagi (67th, 82nd) and Joe Aribo (75th) netted for Rangers.
Porto suffered a 2-1 loss to Bayer while FC Basel finished 3-0 victors over Apoel Nicosia. Roma beat Gent with Carles Perez scoring the only goal of the match in the 13th minute.
United's Martial raced through to level on a night which started with Emmanuel Dennis catching Red Devils goalkeeper Sergio Romero in no man's land.
The Argentina international's poor positioning from former Liverpool stopper Simon Mignolet's goal-kick in the 15th minute summed up a largely poor first-half performance by the visitors.
Brugge looked well placed to secure the "miracle" win their head coach Philippe Clement spoke of in the build-up but they shot themselves in the foot in the 36th minute.
From a throw-in that Harry Maguire had comically given away, Brandon Mechele's bizarre decision to let the ball bounce was gobbled up by Martial and the striker darted through to level coolly.
The France international also hit the post as United attempted to end a poor first half with an undeserved lead.
The second period was a more even affair with both sides having chances to take the lead into next week's second leg at Old Trafford.
"It was a difficult game against a well-organised team in difficult conditions," said Solskjaer. "I don't think it was one of the best games that anyone's seen.
"We got an away goal, we got a draw. We go home next week so hopefully we can finish the job."
Getafe earned an impressive 2-0 win over Ajax while there was also a convincing 2-0 away victory for Inter Milan over Ludogrets, where former Spurs midfielder Christian Eriksen scored his first goal for the club.
Eintracht Frankfurt scored a big 4-1 win over Red Bull Salzburg, Shakhtar Donetsk overcame Benfica 2-1 and Sporting Lisbon beat Istanbul Basaksehir 3-1.
Cluj drew 1-1 with Sevilla while Tom Rogic's Celtic had goalkeeper Fraser Forster to thank for their 1-1 draw against Copenhagen in Denmark.
Rogic was an unused substitute as Forster saved a late Jens Stage penalty to earn the Hoops a share of the spoils.
Australian Associated Press
